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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NUP214 All Species: 6.36
Human Site: S646 Identified Species: 15.56
UniProt: P35658 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35658 NP_005076.3 2090 213620 S646 L K S S V L P S P S G R S A Q
Chimpanzee Pan troglodytes XP_001166820 2121 216999 S687 L K S S V L P S P S G R S A Q
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_850680 1239 128658
Cat Felis silvestris
Mouse Mus musculus Q80U93 2085 212960 T646 S P A A G R S T Q T A P S S A
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506900 1777 179054 R388 D P I M A G I R E E I A H F Q
Chicken Gallus gallus XP_425333 1458 152874 Q69 H T R D L L M Q N Q L G E D P
Frog Xenopus laevis NP_001079666 2037 208914 Q645 Q P T V I P S Q A S V Q P N R
Zebra Danio Brachydanio rerio XP_002662271 1013 102782
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W1X4 1711 175157 W322 E A G D T P A W Q Q L T L L D
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_794482 3338 354012 L1895 S V Q T T Q S L P K P S Q P V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.6 N.A. 51.8 N.A. 77.8 N.A. N.A. 53.7 51.9 49.9 26.8 N.A. 25.6 N.A. N.A. 20.6
Protein Similarity: 100 97.7 N.A. 53.6 N.A. 84.6 N.A. N.A. 62.6 58.9 65.7 34.5 N.A. 41.4 N.A. N.A. 33.3
P-Site Identity: 100 100 N.A. 0 N.A. 6.6 N.A. N.A. 6.6 6.6 6.6 0 N.A. 0 N.A. N.A. 6.6
P-Site Similarity: 100 100 N.A. 0 N.A. 40 N.A. N.A. 6.6 13.3 33.3 0 N.A. 0 N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 10 10 10 0 10 0 10 0 10 10 0 20 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 20 0 0 0 0 0 0 0 0 0 10 10 % D
% Glu: 10 0 0 0 0 0 0 0 10 10 0 0 10 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % F
% Gly: 0 0 10 0 10 10 0 0 0 0 20 10 0 0 0 % G
% His: 10 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % H
% Ile: 0 0 10 0 10 0 10 0 0 0 10 0 0 0 0 % I
% Lys: 0 20 0 0 0 0 0 0 0 10 0 0 0 0 0 % K
% Leu: 20 0 0 0 10 30 0 10 0 0 20 0 10 10 0 % L
% Met: 0 0 0 10 0 0 10 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 10 0 0 0 0 10 0 % N
% Pro: 0 30 0 0 0 20 20 0 30 0 10 10 10 10 10 % P
% Gln: 10 0 10 0 0 10 0 20 20 20 0 10 10 0 30 % Q
% Arg: 0 0 10 0 0 10 0 10 0 0 0 20 0 0 10 % R
% Ser: 20 0 20 20 0 0 30 20 0 30 0 10 30 10 0 % S
% Thr: 0 10 10 10 20 0 0 10 0 10 0 10 0 0 0 % T
% Val: 0 10 0 10 20 0 0 0 0 0 10 0 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _